Campus Units

Biomedical Sciences, Veterinary Diagnostic and Production Animal Medicine

Document Type

Article

Publication Version

Submitted Manuscript

Publication Date

2-5-2019

Journal or Book Title

bioRxiv

First Page

540849

DOI

10.1101/540849

Abstract

Bevacizumab-pemetrexed/cisplatin (BEV-PEM/CIS) is a first line therapeutic for advanced non-squamous non-small cell lung cancer (NSCLC). Bevacizumab potentiates PEM/CIS cytotoxicity by inducing transient tumor vasculature normalization. BEV-PEM/CIS has a narrow therapeutic window. Therefore, it is an attractive target for administration schedule optimization. The present study leverages our previous work on BEV-PEM/CIS pharmacodynamic modeling in NSCLC-bearing mice to estimate the optimal gap in the scheduling of sequential BEV-PEM/CIS. We predicted the optimal gap in BEV-PEM/CIS dosing to be 2.0 days in mice and 1.2 days in humans. Our simulations suggest that the efficacy loss in scheduling BEV-PEM/CIS at too great of a gap is much less than the efficacy loss in scheduling BEV-PEM/CIS at too short of a gap.

Comments

This is a pre-print of the article Schneider, Benjamin, Arnaud Boyer, Joseph Ciccolini, Fabrice Barlési, Kenneth Wang, Sébastien Benzekry, and Jonathan Paul Mochel. "Optimal Scheduling of Bevacizumab and Pemetrexed/Cisplatin Dosing in Non-Small Cell Lung Cancer." bioRxiv (2019): 540849. DOI: 10.1101/540849. Posted with permission.

Copyright Owner

The Authors

Language

en

File Format

application/pdf

Published Version

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