Campus Units

Biomedical Sciences, Food Science and Human Nutrition, Psychology, Veterinary Clinical Sciences

Document Type

Article

Publication Version

Accepted Manuscript

Publication Date

7-28-2020

Journal or Book Title

The British Journal of Nutrition

Volume

124

Issue

2

First Page

135

Last Page

145

DOI

10.1017/S0007114520000951

Abstract

Epidemiological studies show mixed findings for serum vitamin B12 and both cognitive and regional volume outcomes. No studies to date have comprehensively examined, in non-supplemented individuals, serum B12 level associations with neurodegeneration, hypometabolism, and cognition across the Alzheimer's disease (AD) spectrum. Serum vitamin B12 was assayed from the Alzheimer's Disease Neuroimaging Initiative (ADNI) and the Australian Imaging, Biomarker & Lifestyle Flagship Study of Ageing (AIBL). Voxel-wise analyses regressed B12 levels against regional gray matter (GM) volume and glucose metabolism (p

Comments

This article has been published in a revised form in The British Journal of Nutrition. DOI: 10.1017/S0007114520000951. This version is free to view and download for private research and study only. Not for re-distribution or re-use. © The Authors. Posted with permission.

Copyright Owner

The Authors

Language

en

File Format

application/pdf

Published Version

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