Biomedical Sciences, Food Science and Human Nutrition, Psychology, Veterinary Clinical Sciences
Journal or Book Title
The British Journal of Nutrition
Epidemiological studies show mixed findings for serum vitamin B12 and both cognitive and regional volume outcomes. No studies to date have comprehensively examined, in non-supplemented individuals, serum B12 level associations with neurodegeneration, hypometabolism, and cognition across the Alzheimer's disease (AD) spectrum. Serum vitamin B12 was assayed from the Alzheimer's Disease Neuroimaging Initiative (ADNI) and the Australian Imaging, Biomarker & Lifestyle Flagship Study of Ageing (AIBL). Voxel-wise analyses regressed B12 levels against regional gray matter (GM) volume and glucose metabolism (p
McLiman, K. E.; Collazo Martinez, A. D.; Mochel, Jonathan P.; Allenspach, Karin D.; and Willette, Auriel A., "Serum vitamin B12 and related 5-methyltetrahydrofolate-homocysteine methyltransferase reductase and cubilin genotypes predict neural outcomes across the Alzheimerʼs disease spectrum" (2020). Biomedical Sciences Publications. 84.