Campus Units
Biomedical Sciences, Food Science and Human Nutrition, Psychology, Veterinary Clinical Sciences
Document Type
Article
Publication Version
Accepted Manuscript
Publication Date
3-2020
Journal or Book Title
The British Journal of Nutrition
DOI
10.1017/S0007114520000951
Abstract
Epidemiological studies show mixed findings for serum vitamin B12 and both cognitive and regional volume outcomes. No studies to date have comprehensively examined, in non-supplemented individuals, serum B12 level associations with neurodegeneration, hypometabolism, and cognition across the Alzheimer's disease (AD) spectrum. Serum vitamin B12 was assayed from the Alzheimer's Disease Neuroimaging Initiative (ADNI) and the Australian Imaging, Biomarker & Lifestyle Flagship Study of Ageing (AIBL). Voxel-wise analyses regressed B12 levels against regional gray matter (GM) volume and glucose metabolism (p
Copyright Owner
The Author(s)
Copyright Date
2020
Language
en
File Format
application/pdf
Recommended Citation
McLiman, K. E.; Collazo Martinez, A. D.; Mochel, Jonathan P.; Allenspach, Karin D.; and Willette, Auriel A., "Serum Vitamin B12, and Related MTRR and Cubilin Genotypes, Predict Neural Outcomes across the AD Spectrum" (2020). Biomedical Sciences Publications. 84.
https://lib.dr.iastate.edu/bms_pubs/84
Included in
Food Science Commons, Molecular, Genetic, and Biochemical Nutrition Commons, Neurology Commons, Neuroscience and Neurobiology Commons
Comments
This article has been accepted for publication and will appear in a revised form, subsequent to editorial input by Cambridge University Press, in The British Journal of Nutrition published by Cambridge University Press. DOI: 10.1017/S0007114520000951. Posted with permission.