Campus Units

Biomedical Sciences, Veterinary Clinical Sciences

Document Type

Article

Publication Version

Submitted Manuscript

Publication Date

11-13-2020

Journal or Book Title

Preprints

First Page

2020110364

DOI

10.20944/preprints202011.0364.v1

Abstract

Urinary bladder cancer (UBC) is the most common malignancy of the urinary tract in humans, with an estimated global prevalence of 1.1 million cases over 5 years. Due to high rates of recurrence and resistance to chemotherapy, UBC is one of the most expensive cancers to treat, resulting in significant health care costs. There is, therefore, a critical need to develop innovative molecular and cellular tools to refine patient stratification and help predict response to treatment. Urine is an underused resource of biological components shed from bladder tumors, such as exfoliated cells and extracellular vesicles, that could serve as molecular fingerprints and provide valuable biological insights into tumor phenotype and mechanisms of resistance to chemotherapy. Additionally, characterization of urine-derived extracellular vesicles and cells could be used as reliable biomarkers for prediction of response to neoadjuvant therapy.

Comments

This is a pre-print of the article Minkler, Sarah, Fabrice Lucien, Michael Kimber, Agnes Bourgois-Mochel, Margareth Musser, Chad Johannes, Igor Frank, John Cheville, Karin Allenspach, and Jonathan Mochel. "Emerging Roles of Urine-Derived Components for the Management of Bladder Cancer: One Man’s Trash is Another Man’s Treasure." Preprints (2020). DOI: 10.20944/preprints202011.0364.v1. Posted with permission.

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

Copyright Owner

The Author(s)

Language

en

File Format

application/pdf

Published Version

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