Campus Units

Biomedical Sciences

Document Type

Article

Publication Version

Accepted Manuscript

Publication Date

8-2020

Journal or Book Title

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms

Volume

1863

Issue

8

First Page

194562

DOI

10.1016/j.bbagrm.2020.194562

Abstract

Human Survival Motor Neuron (SMN) genes code for SMN, an essential multifunctional protein. Complete loss of SMN is embryonic lethal, while low levels of SMN lead to spinal muscular atrophy (SMA), a major genetic disease of children and infants. Reduced levels of SMN are associated with the abnormal development of heart, lung, muscle, gastro-intestinal system and testis. The SMN loci have been shown to generate a vast repertoire of transcripts, including linear, back- and trans-spliced RNAs as well as antisense long noncoding RNAs. However, functions of the majority of these transcripts remain unknown. Here we review the nature of RNAs generated from the SMN loci and discuss their potential functions in cellular metabolism.

Comments

This is a manuscript of an article published as Singh, Natalia N., Eric W. Ottesen, and Ravindra N. Singh. "A survey of transcripts generated by spinal muscular atrophy genes." Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms 1863, no. 8 (2020): 194562. DOI: 10.1016/j.bbagrm.2020.194562. Posted with permission.

Copyright Owner

Elsevier B.V.

Language

en

File Format

application/pdf

Published Version

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