Campus Units

Chemical and Biological Engineering, Genetics, Development and Cell Biology, Electrical and Computer Engineering

Document Type

Conference Proceeding

Conference

2016 IEEE SENSORS

Publication Version

Accepted Manuscript

Link to Published Version

https://doi.org/10.1109/ICSENS.2016.7808800

Publication Date

2016

Journal or Book Title

IEEE SENSORS

First Page

1

Last Page

3

Research Focus Area

Health Care Technology and Biomedical Engineering

DOI

10.1109/ICSENS.2016.7808800

Conference Title

2016 IEEE SENSORS

Conference Date

Oct. 30-Nov. 3, 2016

City

Orlando, FL

Abstract

This paper reports, for the first time, an optimized microfluidic droplet device for fabricating 3D microtissues and studying the cell behaviors in 3D microtissues. It has been found by properly selecting the size of the microchambers on the microfluidic device and choosing an optimal concentration of collagen (2 mg/ml) to fabricate microtissues, the behaviors of cells in the microtissues can be essentially the same as those of cells in a conventional cell culture system. The normal cell spreading and division in the microtissue have been observed, and the cell migration speed is ~14.1 μm/hr, close to that of 17.3 μm/hr in a macroscale tissue. All these experimental results suggest the microfluidic droplet device might provide a new avenue to replace other approaches to fabricate 3D microtissues and study cell behaviors.

Comments

This is a manuscript of a proceeding published as Che, Xiangchen, Shenmin Gong, Long Que, Jacob Nuhn, and Ian Schneider. "Studies of cell behaviors in 3D microtissues in a microfluidic device: growth and migration." In 2016 IEEE SENSORS. (2016): 1-3. DOI: 10.1109/ICSENS.2016.7808800. Posted with permission.

Rights

© 2016 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.

Copyright Owner

IEEE

Language

en

File Format

application/pdf

Published Version

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