Document Type
Article
Publication Date
2010
Journal or Book Title
Industrial & Engineering Chemistry Research
Volume
49
First Page
10651
Last Page
10662
DOI
10.1021/ie100558n
Abstract
A model study has been conducted for Flash Nanoprecipitation (FNP)sa novel approach to produce functional nanoparticles. A population balance equation with the FNP kinetics has been integrated into a computational fluid dynamics (CFD) simulation of a custom-designed microscale multi-inlet vortex reactor (MIVR) to yield conditions comparable to the real experimental settings. In coping with the complicated aggregation model in the CFD code, a new numerical approach, the conditional quadrature method of moments (CQMOM), has been proposed, which is capable of solving the multivariate system efficiently and accurately. It is shown that the FNP process is highly influenced by mixing effects in the microreactor, and thus coupling CFD with the kinetics model is essential in obtaining valid comparisons with experiments.
Copyright Owner
American Chemical Society
Copyright Date
2010
Language
en
File Format
application/pdf
Recommended Citation
Cheng, Janine C. and Fox, Rodney O., "Kinetic Modeling of Nanoprecipitation using CFD Coupled with a Population Balance" (2010). Chemical and Biological Engineering Publications. 118.
https://lib.dr.iastate.edu/cbe_pubs/118
Comments
This article is from Industrial & Engineering Chemistry Research 49 (2010): 10651-10662, doi: 10.1021/ie100558n. Posted with permission.