Document Type
Article
Publication Date
2011
Journal or Book Title
Tissue Engineering - Part A
Volume
17
Issue
19-20
First Page
2533
Last Page
2541
DOI
10.1089/ten.tea.2011.0095
Abstract
Several challenges currently exist for rational design of functional tissue engineering constructs within the host, which include appropriate cellular integration, avoidance of bacterial infections, and low inflammatory stimulation. This work describes a novel class of biodegradable, amphiphilic polyanhydrides with many desirable protein-material and cell-material attributes capable of confronting these challenges. The biocompatible amphiphilic polymer films were shown to release laminin in a stable and controlled manner, promote neural cell adhesion and differentiation, and evade inflammatory responses of the immune system. Using high-throughput approaches, it was shown that polymer chemistry plays an integral role in controlling cell-film interactions, which suggests that these polyanhydrides can be tailored to achieve the desired cell adhesion and differentiation while minimizing immune recognition. These findings have important implications for development of engineered constructs to regulate differentiation and target the growth of transplanted cells in stem cell-based therapies to treat nervous system disorders.
Copyright Owner
Mary Ann Liebert
Copyright Date
2011
Language
en
File Format
application/pdf
Recommended Citation
Petersen, Latrisha K.; Oh, Jisun; Sakaguchi, Donald S.; Mallapragada, Surya K.; and Narasimhan, Balaji, "Amphiphilic polyanhydride films promote neural stem cell adhesion and differentiation" (2011). Chemical and Biological Engineering Publications. 156.
https://lib.dr.iastate.edu/cbe_pubs/156
Included in
Biochemical and Biomolecular Engineering Commons, Cell and Developmental Biology Commons, Genetics Commons
Comments
This is a copy of an article published in Tissue Engineering - Part A, © 2011 Mary Ann Liebert, Inc,; Tissue Engineering - Part A is available online at : http://online.liebertpub.com.