Document Type
Article
Publication Date
10-2012
Journal or Book Title
Biotechnology Letters
Volume
34
Issue
10
First Page
1869
Last Page
1875
DOI
10.1007/s10529-012-0978-4
Abstract
We gathered primary and tertiary structures of acyl-CoA carboxylases from public databases, and established that members of their biotin carboxylase (BC) and biotin carboxyl carrier protein (BCCP) domains occur in one family each and that members of their carboxyl transferase (CT) domains occur in two families. Protein families have members similar in primary and tertiary structure that probably have descended from the same protein ancestor. The BCCP domains complexed with biotin in acyl and acyl-CoA carboxylases transfer bicarbonate ions from BC domains to CT domains, enabling the latter to carboxylate acyl and acyl-CoA moieties. We separated the BCCP domains into four subfamilies based on more subtle primary structure differences. Members of different BCCP subfamilies often are produced by different types of organisms and are associated with different carboxylases.
Copyright Owner
Springer Science+Business Media B.V.
Copyright Date
2012
Language
en
File Format
application/pdf
Recommended Citation
Chen, Yingfei; Elizondo-Noriega, Armando; Cantu, David C.; and Reilly, Peter J., "Structural classification of biotin carboxyl carrier proteins" (2012). Chemical and Biological Engineering Publications. 18.
https://lib.dr.iastate.edu/cbe_pubs/18
Comments
This is a post-print of an article from Biotechnology Letters, 34, no. 10 (October 2012): 1869–1875, doi: 10.1007/s10529-012-0978-4.