Document Type

Article

Research Focus Area

Health Care Technology and Biomedical Engineering

Publication Date

2013

Journal or Book Title

International Journal of Nanomedicine

Volume

8

First Page

2213

Last Page

2225

DOI

10.2147/IJN.S45317

Abstract

Several challenges are associated with current vaccine strategies, including repeated immunizations, poor patient compliance, and limited approved routes for delivery, which may hinder induction of protective immunity. Thus, there is a need for new vaccine adjuvants capable of multi-route administration and prolonged antigen release at the site of administration by providing a depot within tissue. In this work, we designed a combinatorial platform to investigate the in vivo distribution, depot effect, and localized persistence of polyanhydride nanoparticles as a function of nanoparticle chemistry and administration route. Our observations indicated that the route of administration differentially affected tissue residence times. All nanoparticles rapidly dispersed when delivered intranasally but provided a depot when administered parenterally. When amphiphilic and hydrophobic nanoparticles were administered intranasally, they persisted within lung tissue. These results provide insights into the chemistry and route-dependent distribution and tissue-specific association of polyanhydride nanoparticle-based vaccine adjuvants.

Comments

This article is from International Journal of Nanomedicine 8 (2013): 2213, doi: 10.2147/IJN.S45317.

Rights

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Copyright Owner

Petersen et al

Language

en

File Format

application/pdf

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