Journal or Book Title
The microphase separation in polyanhydride random copolymers composed of 1,6-bis(p-carboxyphenoxy)hexane and sebacic acid is described. Though the copolymers are random, the monomers are sufficiently long and the segment-segment interaction parameter is sufficiently high to promote microphase separation when the copolymer is rich in one component. Solid-state NMR spin diffusion experiments and synchrotron small-angle X-ray scattering are used to discern the length scales of the microphase separation. Both techniques reveal a nanostructure with domain sizes less than 25 Ã…. This nanostructure is compared to approximate calculations of chain dimensions based on a random coil model and discussed in the context of the rational design of these materials for drug delivery applications.
American Chemical Society
Kipper, Matthew J.; Hou, Sheng-Shu; Seifert, Soenke; Thiyagarajan, Papannan; Schmidt-Rohr, Klaus; and Narasimhan, Balaji, "Nanoscale morphology of polyanhydride copolymers" (2005). Chemical and Biological Engineering Publications. 204.