Campus Units

Chemical and Biological Engineering, Biomedical Sciences

Document Type

Article

Research Focus Area

Advanced and Nanostructured Materials, Health Care Technology and Biomedical Engineering

Publication Version

Published Version

Publication Date

4-2015

Journal or Book Title

Nanomedicine: Nanotechnology, Biology and Medicine

Volume

11

Issue

3

First Page

751

Last Page

767

DOI

10.1016/j.nano.2014.12.014

Abstract

Interest in nanoneuromedicine has grown rapidly due to the immediate need for improved biomarkers and therapies for psychiatric, developmental, traumatic, inflammatory, infectious and degenerative nervous system disorders. These, in whole or in part, are a significant societal burden due to growth in numbers of affected people and in disease severity. Lost productivity of the patient and his or her caregiver, and the emotional and financial burden cannot be overstated. The need for improved health care, treatment and diagnostics is immediate. A means to such an end is nanotechnology. Indeed, recent developments of health-care enabling nanotechnologies and nanomedicines range from biomarker discovery including neuroimaging to therapeutic applications for degenerative, inflammatory and infectious disorders of the nervous system. This review focuses on the current and future potential of the field to positively affect clinical outcomes.

From the Clinical Editor

Many nervous system disorders remain unresolved clinical problems. In many cases, drug agents simply cannot cross the blood-brain barrier (BBB) into the nervous system. The advent of nanomedicines can enhance the delivery of biologically active molecules for targeted therapy and imaging. This review focused on the use of nanotechnology for degenerative, inflammatory, and infectious diseases in the nervous system.

Comments

This article is published as Gendelman, Howard E., Vellareddy Anantharam, Tatiana Bronich, Shivani Ghaisas, Huajun Jin, Anumantha G. Kanthasamy, Xinming Liu et al. "Nanoneuromedicines for degenerative, inflammatory, and infectious nervous system diseases." Nanomedicine: Nanotechnology, Biology and Medicine 11, no. 3 (2015): 751-767. 10.1016/j.nano.2014.12.014. Posted with permission.

Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

Copyright Owner

The Authors

Language

en

File Format

application/pdf

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