Campus Units

Chemical and Biological Engineering, Materials Science and Engineering, Ames Laboratory

Document Type

Article

Research Focus Area

Health Care Technology and Biomedical Engineering, Advanced and Nanostructured Materials

Publication Version

Accepted Manuscript

Publication Date

2015

Journal or Book Title

Journal of Materials Chemistry B

Volume

3

Issue

34

First Page

6856

Last Page

6870

DOI

10.1039/C5TB00617A

Abstract

Nanocarriers provide a platform to integrate therapy and diagnostics, which is an emerging direction in medical practice. Beyond simply therapeutic functionality, theranostic nanomaterials have been designed to deliver multiple components and imaging agents, facilitating simultaneous and synergistic diagnosis and therapies. In this article, polymeric materials with diverse functionalities and properties for manufacturing theranostic nanomaterials are discussed and compared. We focused on recent advancements in polymeric multifunctional nanomaterials for synergistic theranostics. The drugs and imaging agents were encapsulated within and/or conjugated to the surface of the nanocarriers, according to the fabrication process and carrier type. In parallel with therapy, polymeric multifunctional nanomaterials can be exploited to exhibit distinctive magnetic, electrical, and optical properties for concomitant imaging. This has been accomplished by incorporating various imaging agents, such as fluorescent dyes, biomarkers, quantum dots, metal composites, and magnetic nanoparticles. We discussed theranostic nanomaterial synthesis, carrier fabrication and its applications. By presenting this comprehensive review of the state-of-the-art, we demonstrated that polymeric multifunctional nanomaterials exhibit distinctive advantages and features in theranostics.

Comments

This is a manuscript of an article published as Peng, Haisheng, Xiaoying Liu, Guangtian Wang, Minghui Li, Kaitlin M. Bratlie, Eric Cochran, and Qun Wang. "Polymeric multifunctional nanomaterials for theranostics." Journal of Materials Chemistry B 3, no. 34 (2015): 6856-6870. DOI: 10.1039/C5TB00617A. Posted with permission.

Copyright Owner

The Royal Society of Chemistry

Language

en

File Format

application/pdf

Published Version

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