Campus Units
Chemical and Biological Engineering, Materials Science and Engineering, Neuroscience, Ames Laboratory
Document Type
Article
Research Focus Area
Advanced and Nanostructured Materials, Health Care Technology and Biomedical Engineering
Publication Version
Accepted Manuscript
Publication Date
8-27-2018
Journal or Book Title
Nanoscale
DOI
10.1039/C8NR04073G
Abstract
Neurodegenerative diseases refer to disorders of the central nervous system (CNS) that are caused by neuronal degradations, dysfunctions, or death. Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease (APHD) are regarded as the three major neurodegenerative diseases. There is a vast body of literature on the causes and treatments of these neurodegenerative diseases. However, the main obstacle in developing an effective treatment strategy is the permeability of the treatment components to the blood-brain barrier (BBB). Several strategies have been developed to improve this obstruction. For example, nanomaterials facilitate drug delivery to the BBB due to their size. They have been used widely in nanomedicine and as nanoprobes for diagnosis purposes among others in neuroscience. Nanomaterials in different forms, such as nanoparticles, nanoemulsions, solid lipid nanoparticles (SLN), and liposomes, have been used to treat the neurodegenerative diseases. This review will cover the basic concepts and applications of nanomaterials in the therapy of APHD.
Copyright Owner
The Royal Society of Chemistry
Copyright Date
2018
Language
en
File Format
application/pdf
Recommended Citation
Poovaiah, Nitya; Davoudi, Zahra; Peng, Haisheng; Schlichtmann, Benjamin; Mallapragada, Surya K.; Narasimhan, Balaji; and Wang, Qun, "Treatment of Neurodegenerative Disorders through the Blood-brain Barrier using Nanocarriers" (2018). Chemical and Biological Engineering Publications. 342.
https://lib.dr.iastate.edu/cbe_pubs/342
Included in
Biochemical and Biomolecular Engineering Commons, Biology and Biomimetic Materials Commons, Biomechanics and Biotransport Commons, Nanoscience and Nanotechnology Commons
Comments
This is a manuscript of an article published as Poovaiah, Nitya, Zahra Davoudi, Haisheng Peng, Benjamin Schlichtmann, Surya K. Mallapragada, Balaji Narasimhan, and Qun Wang. "Treatment of Neurodegenerative Disorders through the Blood-brain Barrier using Nanocarriers." Nanoscale (2018). DOI: 10.1039/C8NR04073G. Posted with permission.