Campus Units

Chemical and Biological Engineering, NSF Engineering Research Center for Biorenewable Chemicals

Document Type

Article

Research Focus Area

Catalysis and Reaction Engineering, Renewable Energy

Publication Version

Accepted Manuscript

Publication Date

4-2016

Journal or Book Title

Current Opinion in Biotechnology

Volume

38

First Page

54

Last Page

62

DOI

10.1016/j.copbio.2015.12.017

Abstract

Advances in metabolic engineering have allowed for the development of new biological catalysts capable of selectively de-functionalizing biomass to yield platform molecules that can be upgraded to biobased chemicals using high efficiency continuous processing allowed by heterogeneous chemical catalysis. Coupling these disciplines overcomes the difficulties of selectively activating COH bonds by heterogeneous chemical catalysis and producing petroleum analogues by biological catalysis. We show that carboxylic acids, pyrones, and alcohols are highly flexible platforms that can be used to produce biobased chemicals by this approach. More generally, we suggest that molecules with three distinct functionalities may represent a practical upper limit on the extent of functionality present in the platform molecules that serve as the bridge between biological and chemical catalysis.

Comments

This is a manuscript of an article published as Schwartz, Thomas J., Brent H. Shanks, and James A. Dumesic. "Coupling chemical and biological catalysis: a flexible paradigm for producing biobased chemicals." Current Opinion in Biotechnology 38 (2016): 54-62. DOI: 10.1016/j.copbio.2015.12.017. Posted with permission.

Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

Copyright Owner

Elsevier Ltd.

Language

en

File Format

application/pdf

Published Version

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