Campus Units

Chemical and Biological Engineering, Genetics, Development and Cell Biology

Document Type

Article

Research Focus Area

Health Care Technology and Biomedical Engineering

Publication Version

Published Version

Publication Date

11-2010

Journal or Book Title

Annual Review of Cell and Developmental Biology

Volume

26

First Page

315

Last Page

333

DOI

10.1146/annurev.cellbio.011209.122036

Abstract

Directed cell migration is a physical process that requires dramatic changes in cell shape and adhesion to the extracellular matrix. For efficient movement, these processes must be spatiotemporally coordinated. To a large degree, the morphological changes and physical forces that occur during migration are generated by a dynamic filamentous actin (F-actin) cytoskeleton. Adhesion is regulated by dynamic assemblies of structural and signaling proteins that couple the F-actin cytoskeleton to the extracellular matrix. Here, we review current knowledge of the dynamic organization of the F-actin cytoskeleton in cell migration and the regulation of focal adhesion assembly and disassembly with an emphasis on how mechanical and biochemical signaling between these two systems regulate the coordination of physical processes in cell migration.

Comments

This article is published as Gardel, Margaret L., Ian C. Schneider, Yvonne Aratyn-Schaus, and Clare M. Waterman. "Mechanical integration of actin and adhesion dynamics in cell migration." Annual Review of Cell and Developmental Biology 26 (2010): 315-333. DOI: 10.1146/annurev.cellbio.011209.122036.

Rights

Works produced by employees of the U.S. Government as part of their official duties are not copyrighted within the U.S. The content of this document is not copyrighted.

Language

en

File Format

application/pdf

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