Campus Units
Chemical and Biological Engineering, Genetics, Development and Cell Biology
Document Type
Article
Research Focus Area
Health Care Technology and Biomedical Engineering
Publication Version
Published Version
Publication Date
11-2010
Journal or Book Title
Annual Review of Cell and Developmental Biology
Volume
26
First Page
315
Last Page
333
DOI
10.1146/annurev.cellbio.011209.122036
Abstract
Directed cell migration is a physical process that requires dramatic changes in cell shape and adhesion to the extracellular matrix. For efficient movement, these processes must be spatiotemporally coordinated. To a large degree, the morphological changes and physical forces that occur during migration are generated by a dynamic filamentous actin (F-actin) cytoskeleton. Adhesion is regulated by dynamic assemblies of structural and signaling proteins that couple the F-actin cytoskeleton to the extracellular matrix. Here, we review current knowledge of the dynamic organization of the F-actin cytoskeleton in cell migration and the regulation of focal adhesion assembly and disassembly with an emphasis on how mechanical and biochemical signaling between these two systems regulate the coordination of physical processes in cell migration.
Rights
Works produced by employees of the U.S. Government as part of their official duties are not copyrighted within the U.S. The content of this document is not copyrighted.
Language
en
File Format
application/pdf
Recommended Citation
Gardel, Margaret L.; Schneider, Ian C.; Aratyn-Schaus, Yvonne; and Waterman, Clare M., "Mechanical Integration of Actin and Adhesion Dynamics in Cell Migration" (2010). Chemical and Biological Engineering Publications. 435.
https://lib.dr.iastate.edu/cbe_pubs/435
Included in
Biomechanics and Biotransport Commons, Molecular, Cellular, and Tissue Engineering Commons
Comments
This article is published as Gardel, Margaret L., Ian C. Schneider, Yvonne Aratyn-Schaus, and Clare M. Waterman. "Mechanical integration of actin and adhesion dynamics in cell migration." Annual Review of Cell and Developmental Biology 26 (2010): 315-333. DOI: 10.1146/annurev.cellbio.011209.122036.