Campus Units

Chemical and Biological Engineering, Materials Science and Engineering, Neuroscience, Ames Laboratory, Nanovaccine Institute, Veterinary Microbiology and Preventive Medicine

Document Type

Article

Research Focus Area

Advanced and Nanostructured Materials, Health Care Technology and Biomedical Engineering

Publication Version

Published Version

Publication Date

8-4-2021

Journal or Book Title

Science Advances

Volume

7

Issue

32

First Page

eabj1691

DOI

10.1126/sciadv.abj1691

Abstract

Host antibody responses are pivotal for providing protection against infectious agents. We have pioneered a new class of self-assembling micelles based on pentablock copolymers that enhance antibody responses while providing a low inflammatory environment compared to traditional adjuvants. This type of “just-right” immune response is critical in the rational design of vaccines for older adults. Here, we report on the mechanism of enhancement of antibody responses by pentablock copolymer micelles, which act as scaffolds for antigen presentation to B cells and cross-link B cell receptors, unlike other micelle-forming synthetic block copolymers. We exploited this unique mechanism and developed these scaffolds as a platform technology to produce antibodies in vitro. We show that this novel approach can be used to generate laboratory-scale quantities of therapeutic antibodies against multiple antigens, including those associated with SARS-CoV-2 and Yersinia pestis, further expanding the value of these nanomaterials to rapidly develop countermeasures against infectious diseases.

Comments

This article is published as Senapati, Sujata, Ross J. Darling, Kathleen A. Ross, Michael J. Wannemeuhler, Balaji Narasimhan, and Surya K. Mallapragada. "Self-assembling synthetic nanoadjuvant scaffolds cross-link B cell receptors and represent new platform technology for therapeutic antibody production." Science Advances 7, no. 32 (2021): eabj1691. DOI: 10.1126/sciadv.abj1691. Posted with permission.

Creative Commons License

Creative Commons Attribution-NonCommercial 4.0 International License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License

Copyright Owner

The Authors

Language

en

File Format

application/pdf

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