Document Type

Article

Publication Date

11-2-2010

Journal or Book Title

Nucleic Acids Research

Volume

39

First Page

D342

Last Page

D346

DOI

10.1093/nar/gkq1072

Abstract

The ThYme (Thioester-active enzYme;http://www.enzyme.cbirc.iastate.edu) database has been constructed to bring together amino acid sequences and 3D (tertiary) structures of all the enzymes constituting the fatty acid synthesis and polyketide synthesis cycles. These enzymes are active on thioester-containing substrates, specifically those that are parts of the acyl-CoA synthase, acyl-CoA carboxylase, acyl transferase, ketoacyl synthase, ketoacyl reductase, hydroxyacyl dehydratase, enoyl reductase and thioesterase enzyme groups. These groups have been classified into families, members of which are similar in sequences, tertiary structures and catalytic mechanisms, implying common protein ancestry. ThYme is continually updated as sequences and tertiary structures become available.

Comments

Published in Nucleic Acids Research, 39 (2011): D342-D346. doi: 10.1093/nar/gkq1072.

Copyright Owner

The author(s)

Language

en

File Format

application/pdf

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