Document Type

Article

Research Focus Area

Health Care Technology and Biomedical Engineering

Publication Date

2013

Journal or Book Title

Tissue Engineering: Part A

Volume

19

Issue

23-24

First Page

2586

Last Page

2593

DOI

10.1089/ten.tea.2013.0075

Abstract

Injectable bone fillers have emerged as an alternative to the invasive surgery often required to treat bone defects. Current bone fillers may benefit from improvements in dynamic properties such as shear thinning during injection and recovery of material stiffness after placement. Negatively charged inorganic hydroxyapatite (HAp) nanoparticles (NPs) were assembled with positively charged organic poly(d,l-lactic-co-glycolic acid) (PLGA) NPs to create a cohesive colloidal gel. This material is held together by electrostatic forces that may be disrupted by shear to facilitate extrusion, molding, or injection. Scanning electron micrographs of the dried colloidal gels showed a well-organized, three-dimensional porous structure. Rheology tests revealed that certain colloidal gels could recover after being sheared. Human umbilical cord mesenchymal stem cells were also highly viable when seeded on the colloidal gels. HAp/PLGA NP colloidal gels offer an attractive scheme for injectable filling and regeneration of bone tissue.

Rights

This is a copy of an article published in Tissue Engineering: Part A © 2013 copyright Mary Ann Liebert, Inc; Tissue Engineering: Part A is available online at: http://online.liebertpub.com.

Copyright Owner

Mary Ann Liebert, Inc.

Language

en

File Format

application-pdf

Share

COinS