Document Type

Article

Research Focus Area

Health Care Technology and Biomedical Engineering

Publication Date

2013

Journal or Book Title

ACS Nano

Volume

7

Issue

5

First Page

4194

Last Page

4201

DOI

10.1021/nn400630x

Abstract

Diabetes mellitus, a disorder of glucose regulation, is a global burden affecting 366 million people across the world. An artificial “closed-loop” system able to mimic pancreas activity and release insulin in response to glucose level changes has the potential to improve patient compliance and health. Herein we develop a glucose-mediated release strategy for the self-regulated delivery of insulin using an injectable and acid-degradable polymeric network. Formed by electrostatic interaction between oppositely charged dextran nanoparticles loaded with insulin and glucose-specific enzymes, the nanocomposite-based porous architecture can be dissociated and subsequently release insulin in a hyperglycemic state through the catalytic conversion of glucose into gluconic acid. In vitro insulin release can be modulated in a pulsatile profile in response to glucose concentrations. In vivo studies validated that these formulations provided improved glucose control in type 1 diabetic mice subcutaneously administered with a degradable nano-network. A single injection of the developed nano-network facilitated stabilization of the blood glucose levels in the normoglycemic state (<200 mg/dL) for up to 10 days.

Rights

Reprinted from "Injectable Nano-Network for Glucose-Mediated Insulin Delivery" by Zhen Gu, Alex A. Aimetti, Qun Wang, Tram T. Dang, Yunlong Zhang, Omid Veiseh, Hao Cheng, Robert S. Langer, and Daniel G. Anderson ACS Nano 2013 7 (5), 4194-4201 Copyright 2013 American Chemical Society

Copyright Owner

American Chemical Society

Language

en

File Format

application-pdf

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