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Crimean-Congo hemorrhagic fever (CCHF) is a zoonotic viral disease that is asymptomatic in infected animals, but a serious threat to humans. Human infections begin with nonspecific febrile symptoms, but progress to a serious hemorrhagic syndrome with a high case fatality rate. Although the causative virus is often transmitted by ticks, animal-to-human and human-to-human transmission also occur. This disease is a particular threat to farmers and other agricultural workers, veterinarians, laboratory workers and hospital personnel.

Crimean-Congo hemorrhagic fever is one of the most widely distributed viral hemorrhagic fevers. This disease occurs in much of Africa, the Middle East and Asia, as well as parts of Europe. Changes in climatic conditions could expand the range of its tick vectors, and increase the incidence of disease. The CCHF virus is also a potential bioterrorist agent; it has been listed in the U.S. as a CDC/NIAID Category C priority pathogen.

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Iowa State University



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