A method and system are provided that prioritize the output of an image triage that is based on rapid serial visual presentation. User responses and estimates of the effectiveness with which each image is likely to have been processed by a user are employed for post triage image prioritization of potential targets. Images associated with a user response, processed during optimal user states, are assigned the highest priority for post triage examination, as targets are likely. Images without a user response that are processed during optimal user states are assigned the lowest priority, as these are unlikely to contain targets. Images with a user response that are processed during suboptimal states are assigned a medium priority, as these are likely to contain a high number of false positives. Images without a user response, processed during suboptimal user states are flagged for reprocessing as these may contain targets that the user may not have detected.