Porcine Reproductive and Respiratory Syndrome virus (PRRS)V is known to cause persistent infections in swine populations. We inoculated three week-old feeder pigs with PRRSV (ATCC VR-2332) then collected and analyzed biological samples to determine the pigs’ infection status over time post-inoculation (PI). Infectious virus was detected in 100% of animals at 63 days post inoculation and 90% of animals were still carrying infectious virus at 105 days PI.