Vitamin D status in cats with cardiomyopathy

Ware, Wendy; Freeman, Lisa; Rush, John; Ward, Jessica; Ward, Jessica; Makowski, Andrew; Zhang, Min

Vitamin D status in cats with cardiomyopathy

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2020_WardJessica_VitaminD.pdf (775 KB)

Date

2020-06-17

Authors

Ware, Wendy

Freeman, Lisa

Rush, John

Ward, Jessica

Makowski, Andrew

Zhang, Min

Authors

Person

Ward, Jessica

Assistant Dean for Extramural Student Programs

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Veterinary Clinical Sciences

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Statistics

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Veterinary Diagnostic and Production Animal Medicine

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Department

Veterinary Clinical SciencesStatisticsVeterinary Diagnostic and Production Animal Medicine

Abstract

Background Low vitamin D concentrations have been associated with advanced heart disease and poorer outcomes in people and dogs. Vitamin D status typically is assessed by serum 25(OH)D concentration. However, cats also produce notable amounts of a C‐3 epimer of 25(OH)D (3‐epi).

Hypothesis/Objectives Determine if vitamin D status, estimated by 25(OH)D3 alone or combined with 3‐epi (summation vitD), is lower in cats with cardiomyopathy (CM) compared to clinically normal (N) cats and if indicators of disease severity are associated with vitamin D status.

Animals Privately owned cats, 44 with CM and 56 N.

Methods Cross‐sectional observational study using clinical and echocardiographic findings, diet history, and serum 25(OH)D3 and 3‐epi measurements.

Results Cat age was negatively related to vitamin D status. Summation vitD was lower in CM cats (median = 47.1 ng/mL) compared to N cats (median = 58.65 ng/mL) both before (P = .03) and after (P = .04) accounting for age. However, 25(OH)D3 became nonsignificant between CM and N cats after age was included. Summation vitD was related positively to survival time and fractional shortening (FS), but negatively to left atrial enlargement (LAE) severity, both before and after accounting for age. For 25(OH)D3 alone, only survival time and FS remained significant after including age.

Conclusions and Clinical Importance We report 25(OH)D3 and 3‐epi concentrations in CM and N cats. Age had an important (negative) relationship to vitamin D status. After accounting for age, summation vitD was lower in CM cats. Vitamin D status was related positively to survival time and FS, but negatively to LAE severity.

Comments

This is the published version of the following article: Ware, Wendy A., Lisa M. Freeman, John E. Rush, Jessica L. Ward, Andrew J. Makowski, and Min Zhang. "Vitamin D status in cats with cardiomyopathy." Journal of Veterinary Internal Medicine. (2020). DOI: 10.1111/jvim.15833. Posted with permission.

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Wed Jan 01 00:00:00 UTC 2020

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