A 5-year-old Suffolk ewe maintained as breeding stock in a scrapie-free flock at the USDA National Animal Disease Center was euthanized (by IV overdose of sodium pentobarbital) because of poor reproductive performance and underwent necropsy. The ewe had given birth to 5 lambs in 3 prior lambings, but its fourth breeding season resulted in no offspring. The ewe had been exposed to a ram for 40 days during the breeding season; records reflected that the ewe had been observed being mated but failed to conceive or carry offspring to term.