Pigs were inoculated with virus-like replicon particle (VRP) vaccines expressing the influenza hemagglutinin (HA) protein. A robust antibody response was present following the inoculation. These results indicate that VRP vaccines can successfully express a foreign antigen in the pig and induce high antibody titers. This proof of concept work supports the further in vivo evaluation of VRP expressing swine influenza virus (SIV) HA protein as well as VRP co-expressing porcine reproductive and respiratory syndrome virus (PRRSV) GP5 and M proteins as novel vaccines for swine.