The purpose of the genomic initiative project that is described herein is to use high-density single nucleotide polymorphism (SNP) marker genotypes on sires from commercial broiler lines and mean performance of their progeny to identify regions of the genome that are associated with economic traits. This report addresses some of the methodological aspects considered during analysis and interpretation of the data. Considering the large amount of phenotypic and SNP data, the data were analyzed separately for each line using mixed models procedures. Results were then pooled across lines to determine overall significance. Preliminary results showed important association of several genomic regions with mean progeny performance. But, the degree of significance was influenced by the size of heritability value used. Results from this project will be an important step towards implementation of marker-assisted selection in commercial broiler breeding programs.