Serological Response of Swine to an Attenuated Salmonella enterica serovar Typhimurium Strain that Reduces Gastrointestinal Colonization, Fecal Shedding and Disease due to Virulent Salmonella Typhimurium
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The SafePork conference series began in 1996 to bring together international researchers, industry, and government agencies to discuss current Salmonella research and identify research needs pertaining to both pig and pork production. In subsequent years topics of research presented at these conferences expanded to include other chemical and biological hazards to pig and pork production.
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Abstract
Swine are often asymptomatic carriers of Salmonella spp. Interventions are needed to limit Salmonella colonization of swine to enhance food safety. An attenuated Salmonella enterica serovar Typhimurium mutant strain (BBS 202) was tested in swine to determine whether vaccination could provide protection against wild-type S. Typhimurium challenge. Two groups of piglets (n=14/group) received an intranasal inoculation of BBS 202 or a PBS placebo at 6-weeks of age with a booster 2-weeks later. At 11-weeks of age, all pigs were challenged with the parental, wild-type S. Typhimurium by intranasal inoculation.