The objective of this study was to derive and evaluate the accuracies of molecular breeding values (MBV) for economically relevant traits for commercial implementation in several beef cattle breeds. We developed MBV forHereford, Red Angus and Simmental breeds. Accuracies of MBV ranged from 0.18 to 0.45 in Hereford, 0.37 to 0.85 in Red Angus, and from 0.29 to 0.65 in Simmental using within breed genomic predictions. Single breed genomic predictions had no utility when applied to other breeds. However, the accuracies of MBV improved for some breeds when predictions were derived using multi-breed reference populations. These results have now been implemented as routine predictions for breeders of American Hereford, American Red Angus and American Simmental beef cattle. Similar findings will soon be extended to other breeds.