Heterocycles from wine: synthesis and biological evaluation of salidrosides

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2015-05-20
Authors
Guney, Tezcan
Kohles, Stephanie
Thompson, Victoria
Phillips, Gregory
Kraus, George
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Kraus, George
University Professor Emeritus
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Veterinary Microbiology and Preventive Medicine
Our faculty promote the understanding of causes of infectious disease in animals and the mechanisms by which diseases develop at the organismal, cellular and molecular levels. Veterinary microbiology also includes research on the interaction of pathogenic and symbiotic microbes with their hosts and the host response to infection.
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Chemistry

The Department of Chemistry seeks to provide students with a foundation in the fundamentals and application of chemical theories and processes of the lab. Thus prepared they me pursue careers as teachers, industry supervisors, or research chemists in a variety of domains (governmental, academic, etc).

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The Department of Chemistry was founded in 1880.

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Veterinary Microbiology and Preventive MedicineChemistry
Abstract

Wine is composed of a variety of tannins, of which a sub-class includes salidrosides, which are largely uninvestigated compounds. The first syntheses of galloylated salidrosides are reported in 7 steps from commercially available starting materials through a platform approach. The antimicrobial activity of the salidrosides against Escherichia coli strains is described.

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This is a manuscript of an article published as Guney, Tezcan, Stephanie A. Kohles, Victoria L. Thompson, Gregory J. Phillips, and George A. Kraus. "Heterocycles from wine: synthesis and biological evaluation of salidrosides." Tetrahedron 71, no. 20 (2015): 3115-3119. DOI: 10.1016/j.tet.2014.08.065. Posted with permission.

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Wed Jan 01 00:00:00 UTC 2014
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