Enhancing binding affinity and selectivity through preorganization and cooperative enhancement of the receptor
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The Department of Chemistry seeks to provide students with a foundation in the fundamentals and application of chemical theories and processes of the lab. Thus prepared they me pursue careers as teachers, industry supervisors, or research chemists in a variety of domains (governmental, academic, etc).
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The Department of Chemistry was founded in 1880.
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1880-present
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- College of Liberal Arts and Sciences (parent college)
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Abstract
When direct host–guest binding interactions are weakened by unfavorable solvent competition, guest-triggered intrareceptor interactions could be used to augment the binding. This strategy of cooperative enhancement, when combined with the principle of preorganization, yielded a strong and selective receptor for binding citrate in water.
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This is a manuscript of an article published as Gunasekara, Roshan W., and Yan Zhao. "Enhancing binding affinity and selectivity through preorganization and cooperative enhancement of the receptor." Chemical Communications 52, no. 23 (2016): 4345-4348. DOI: 10.1039/C5CC10405J. Posted with permission.