Relationship of the mucosal microbiota to gastrointestinal inflammation and the presence of small cell intestinal lymphoma in cats

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2018-01-01
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Garraway, Kayode
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Albert Jergens
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Veterinary Clinical Sciences
The mission of the Veterinary Clinical Sciences Department and the Veterinary Medical Center is to be strong academically, to provide outstanding services, and to conduct research in the multiple areas of Veterinary Clinical Sciences. Our goals are to teach students in the multiple disciplines of Veterinary Clinical Sciences, to provide excellent veterinary services to clients, and to generate and disseminate new knowledge in the areas of Veterinary Clinical Sciences. Our objectives are to provide a curriculum in the various aspects of Veterinary Clinical Sciences which ensures students acquire the skills and knowledge to be successful in their chosen careers. We also strive to maintain a caseload of sufficient size and diversity which insures a broad clinical experience for students, residents, and faculty. In addition, we aim to provide clinical veterinary services of the highest standards to animal owners and to referring veterinarians. And finally, we strive to provide an environment and opportunities which foster and encourage the generation and dissemination of new knowledge in many of the disciplines of Veterinary Clinical Sciences.
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Abstract

The gastrointestinal (GI) microbiota in healthy cats is altered in IBD. Little research has been performed to identify whether specific bacterial groups are associated with small cell GI lymphoma (LSA).

Fourteen cats with IBD and 14 cats with small cell GI LSA were included in this retrospective case control study. A search of the medical records was performed to identify cats diagnosed with IBD and with GI LSA. Bacterial groups identified by FISH in GI biopsies were compared between cohorts and correlated to CD11b+ and NF-kappaB expression.

Fusobacterium spp. were higher in cats with small cell GI LSA in ileal and colonic adherent mucus, and combined colonic compartments compared to cats with IBD. Bacteroides spp. were higher in ileal adherent mucus and 3 combined ileal compartments of cats with small cell GI LSA. There were significant correlations between Fusobacterium spp. totals and CD11b+ cell and NF-kappaB expression.

The bacterial alterations appreciated might be influential in development of small cell GI LSA, and should drive further studies to elucidate the effects of microbial-mediated inflammation on GI cancer progression.
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https://dr.lib.iastate.edu/handle/20.500.12876/31371
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Veterinary Medicine
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Wed Aug 01 00:00:00 UTC 2018
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