Campus Units

Chemistry, Veterinary Microbiology and Preventive Medicine, Ames Laboratory

Document Type

Conference Proceeding

Conference

Optics, Electro-Optics, and Laser Applications in Science and Engineering

Publication Version

Published Version

Publication Date

6-1-1991

Journal or Book Title

Proceedings of SPIE. Optical Methods for Tumor Treatment and Early Diagnosis: Mechanisms and Techniques

Volume

1426

First Page

228

Last Page

234

DOI

10.1117/12.44062

Conference Title

Optics, Electro-Optics, and Laser Applications in Science and Engineering

Conference Date

January 20-25, 1991

City

Los Angeles, CA

Abstract

In a seminal series of papers, Meruelo and co-workers have described the potent antiretroviral effect of hypericin. Interestingly, hypericin was found to inhibit not only the production of infectious virus from chronically infected cells, but was also shown to directly inhibit reverse transcriptase activity of mature virions. The effect of hypericin on cells chronically infected with equine infectious anemia virus (EIAV), a retrovirus genetically related to HIV, is demonstrated. At concentrations of 10 (mu) g/ml, hypericin reduced production of infectious EIAV by 99.99 without causing obvious cytopathic effects. Interestingly, the results indicated that the antiretroviral activity of hypericin was wholly dependent on the presence of light. No decrease in viral infectivity was observed when hypericin and virus were incubated in the dark. Moreover, it appeared that light was an absolute requirement for the antiviral activity, as even high concentrations of hypericin (10 (mu) g/ml) were unable to reduce infectivity of as few as 100 infectious virions.

Comments

This proceeding is published as Carpenter, Susan, John Tossberg, and George A. Kraus. "Photosensitization is required for antiretroviral activity of hypericin." In Optical Methods for Tumor Treatment and Early Diagnosis: Mechanisms and Techniques, vol. 1426, pp. 228-234. International Society for Optics and Photonics, 1991. DOI: 10.1117/12.44062. Posted with permission.

Copyright Owner

Society of Photo-Optical Instrumentation Engineers (SPIE)

Language

en

File Format

application/pdf

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