Selective pyrone functionalization: reductive alkylation of triacetic acid lactone
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The Department of Chemistry seeks to provide students with a foundation in the fundamentals and application of chemical theories and processes of the lab. Thus prepared they me pursue careers as teachers, industry supervisors, or research chemists in a variety of domains (governmental, academic, etc).
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The Department of Chemistry was founded in 1880.
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1880-present
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- College of Liberal Arts and Sciences (parent college)
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Abstract
The one-pot reaction of aldehydes, triacetic acid lactone, and Hantzsch 1,4-dihydropyridine affords 3-alkyl pyrones via a reductive alkylation strategy.
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This is a manuscript of an article published as Kraus, George A., Kevin Basemann, and Tezcan Guney. "Selective pyrone functionalization: reductive alkylation of triacetic acid lactone." Tetrahedron Letters 56, no. 23 (2015): 3494-3496. 10.1016/j.tetlet.2015.01.141. Posted with permission.