Molecularly Responsive Binding through Co-occupation of Binding Space: A Lock–Key Story
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The Department of Chemistry seeks to provide students with a foundation in the fundamentals and application of chemical theories and processes of the lab. Thus prepared they me pursue careers as teachers, industry supervisors, or research chemists in a variety of domains (governmental, academic, etc).
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The Department of Chemistry was founded in 1880.
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1880-present
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- College of Liberal Arts and Sciences (parent college)
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Abstract
When two guest molecules co-occupy a binding pocket of a water-soluble host, the first guest could be used as a signal molecule to turn on the binding of the second. This type of molecularly responsive binding strongly depends on the size of the two guests and the location of the signal molecule.
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This is a manuscript of an article published as Awino, Joseph K., Lan Hu, and Yan Zhao. "Molecularly Responsive Binding through Co-occupation of Binding Space: A Lock–Key Story." Organic letters 18, no. 7 (2016): 1650-1653. doi:10.1021/acs.orglett.6b00527. Posted with permission.