Campus Units

Chemistry, Ames Laboratory

Document Type

Article

Publication Version

Published Version

Publication Date

2015

Journal or Book Title

Analytical Chemistry

Volume

87

Issue

8

First Page

4096

Last Page

4099

DOI

10.1021/acs.analchem.5b00604

Abstract

Three-layer core-shell plasmonic nanorods (Au/Ag/SiO2-NRs), consisting of a gold nanorod core, a thin silver shell, and a thin silica layer, were synthesized and used as optical imaging probes under a differential interference contrast microscope for single particle orientation and rotational tracking. The localized surface plasmon resonance modes were enhanced upon the addition of the silver shell, and the anisotropic optical properties of gold nanorods were maintained. The silica coating enables surface functionalization with silane coupling agents and provides enhanced stability and biocompatibility. Taking advantage of the longitudinal LSPR enhancement, the orientation and rotational information of the hybrid nanorods on synthetic lipid bilayers and on live cell membranes were obtained with millisecond temporal resolution using a scientific complementary metal-oxide-semiconductor camera. The results demonstrate that the as-synthesized hybrid nanorods are promising imaging probes with improved sensitivity and good biocompatibility for single plasmonic particle tracking experiments in biological systems.

Comments

Reprinted (adapted) with permission from Analytical Chemistry 87 (2015): 4096, doi: 10.1021/acs.analchem.5b00604. Copyright 2015 American Chemical Society.

Copyright Owner

American Chemical society

Language

en

File Format

application/pdf

Included in

Chemistry Commons

Share

COinS