Chemistry, Ames Laboratory
Journal or Book Title
We report palladium(II)-functionalized MOF-253 (MOF-253-Pd(OAc)2) as a recyclable catalyst to form all-carbon quaternary centers via conjugate additions of arylboronic acids to β,β-disubstituted enones in aqueous media. We demonstrate MOF-253-Pd(OAc)2 can be reused 8 times to form ketone products in yields above 75% while maintaining its crystallinity. Additions of a range of stereoelectronically diverse arylboronic acids to a variety of β,β-disubstituted enones catalyzed by MOF-253-Pd(OAc)2 occur in modest-to-high yields (34–95%).
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The Royal Society of Chemistry
Van Zeeland, Ryan; Li, Xinle; Huang, Wenyu; and Stanley, Levi M., "MOF-253-Pd(OAc)2: a recyclable MOF for transition-metal catalysis in water" (2016). Chemistry Publications. 1042.