Campus Units

Chemistry

Document Type

Article

Publication Version

Published Version

Publication Date

8-2015

Journal or Book Title

Organic Letters

Volume

5

Issue

9

First Page

5203

Last Page

5206

DOI

10.1021/acscatal.5b01272

Abstract

Palladium-catalyzed conjugate addition of arylboronic acids to β,β-disubstituted enones in aqueous media is reported. Additions of a wide range of arylboronic acids to β,β-disubstituted enones occur to form ketone products bearing benzylic all-carbon quaternary centers. These reactions are promoted by a simple catalyst prepared from palladium trifluoracetate and 2,2′-bipyridine. The use of aqueous sodium trifluoracetate as the reaction medium significantly enhances reactivity and enables the formation of challenging bis-benzylic and ortho-substituted benzylic all-carbon quaternary centers.

Comments

Reprinted (adapted) with permission from Organic Letters 5 (2015): 5203, doi:10.1021/acscatal.5b01272. Copyright 2015 American Chemical Society.

Copyright Owner

American Chemical Society

Language

en

File Format

application/pdf

Included in

Chemistry Commons

Share

COinS