Campus Units

Chemistry

Document Type

Article

Publication Version

Published Version

Publication Date

2019

Journal or Book Title

Organic & Biomolecular Chemistry

Volume

17

Issue

37

First Page

8611

Last Page

8617

DOI

10.1039/C9OB01440C

Abstract

Molecular imprinting is a facile method to create guest-complementary binding sites in a cross-linked polymeric network. When performed within cross-linked micelles, the resulting molecularly imprinted nanoparticles (MINPs) exhibited an extraordinary ability to distinguish subtle structural changes in the guest, including the shift of a hydrophilic or hydrophobic group by 1 carbon and addition of a single methylene/methyl group. A high surface-cross-linking density prior to core-cross-linking was key to the high-fidelity imprinting, enhancing both the binding affinity of the imprinted micelle for the template and selectivity among structural analogues. Whereas the imprinted site closely complemented the hydrophilic surface anchoring group and rigid hydrophobic aromatic core, it was expanded significantly for a conformationally mobile small group (i.e., methoxy).

Comments

This article is published as Chen, Kaiqian, and Yan Zhao. "Effects of nano-confinement and conformational mobility on molecular imprinting of cross-linked micelles." Organic & Biomolecular Chemistry 17, no. 37 (2019): 8611-8617. DOI: 10.1039/C9OB01440C. Posted with permission.

Creative Commons License

Creative Commons Attribution-Noncommercial 3.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial 3.0 License

Copyright Owner

The Royal Society of Chemistry

Language

en

File Format

application/pdf

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