Journal or Book Title
Organic and Biomolecular Chemistry
A difficult challenge in synthetic enzymes is the creation of substrate-selective active sites with accurately positioned catalytic groups. Covalent molecular imprinting in cross-linked micelles afforded such active sites in protein-sized, water-soluble nanoparticle catalysts. Our method allowed a systematic tuning of the distance of the catalytic group to the bound substrate. The catalysts displayed enzyme-like kinetics and easily distinguished substrates with subtle structural differences.
The Royal Society of Chemistry
Hu, Lan and Zhao, Yan, "Molecularly imprinted artificial esterases with highly specific active sites and precisely installed catalytic groups" (2018). Chemistry Publications. 1200.