Campus Units

Chemistry

Document Type

Article

Publication Version

Accepted Manuscript

Publication Date

2018

Journal or Book Title

Organic and Biomolecular Chemistry

Volume

16

Issue

31

First Page

5580

Last Page

5584

DOI

10.1039/C8OB01584H

Abstract

A difficult challenge in synthetic enzymes is the creation of substrate-selective active sites with accurately positioned catalytic groups. Covalent molecular imprinting in cross-linked micelles afforded such active sites in protein-sized, water-soluble nanoparticle catalysts. Our method allowed a systematic tuning of the distance of the catalytic group to the bound substrate. The catalysts displayed enzyme-like kinetics and easily distinguished substrates with subtle structural differences.

Comments

This is a manuscript of an article published as Hu, Lan, and Yan Zhao. "Molecularly imprinted artificial esterases with highly specific active sites and precisely installed catalytic groups." Organic & Biomolecular Chemistry 16, no. 31 (2018): 5580-5584. DOI: 10.1039/C8OB01584H. Posted with permission.

Copyright Owner

The Royal Society of Chemistry

Language

en

File Format

application/pdf

Published Version

Included in

Chemistry Commons

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