Campus Units
Chemistry
Document Type
Article
Publication Version
Accepted Manuscript
Publication Date
2018
Journal or Book Title
Organic and Biomolecular Chemistry
Volume
16
Issue
21
First Page
3885
Last Page
3888
DOI
10.1039/C8OB00786A
Abstract
Molecular tweezers using aromatic interactions for binding normally work best in polar instead of nonpolar solvents due to the strong solvophobic effect in the binding. Inspired by biological receptors that utilize “delocalized binding interactions” remote from the binding interface to strengthen guest-binding, we constructed molecular tweezers that have a reversed solvent effect. As the direct aromatic binding interactions were weakened by nonpolar solvent, guest-triggered intrahost interactions between two strategically placed carboxylic acids became stronger and contributed to the binding.
Copyright Owner
The Royal Society of Chemistry
Copyright Date
2018
Language
en
File Format
application/pdf
Recommended Citation
Xing, Xiaoyu and Zhao, Yan, "Intramolecularly enhanced molecular tweezers with unusually strong binding for aromatic guests in unfavorable solvents" (2018). Chemistry Publications. 1201.
https://lib.dr.iastate.edu/chem_pubs/1201
Comments
This is a manuscript of an article published as Xing, Xiaoyu, and Yan Zhao. "Intramolecularly enhanced molecular tweezers with unusually strong binding for aromatic guests in unfavorable solvents." Organic & Biomolecular Chemistry 16, no. 21 (2018): 3885-3888. DOI: 10.1039/C8OB00786A. Posted with permission