Campus Units

Chemistry

Document Type

Article

Publication Version

Accepted Manuscript

Publication Date

2018

Journal or Book Title

Organic and Biomolecular Chemistry

Volume

16

Issue

21

First Page

3885

Last Page

3888

DOI

10.1039/C8OB00786A

Abstract

Molecular tweezers using aromatic interactions for binding normally work best in polar instead of nonpolar solvents due to the strong solvophobic effect in the binding. Inspired by biological receptors that utilize “delocalized binding interactions” remote from the binding interface to strengthen guest-binding, we constructed molecular tweezers that have a reversed solvent effect. As the direct aromatic binding interactions were weakened by nonpolar solvent, guest-triggered intrahost interactions between two strategically placed carboxylic acids became stronger and contributed to the binding.

Comments

This is a manuscript of an article published as Xing, Xiaoyu, and Yan Zhao. "Intramolecularly enhanced molecular tweezers with unusually strong binding for aromatic guests in unfavorable solvents." Organic & Biomolecular Chemistry 16, no. 21 (2018): 3885-3888. DOI: 10.1039/C8OB00786A. Posted with permission

Copyright Owner

The Royal Society of Chemistry

Language

en

File Format

application/pdf

Published Version

Included in

Chemistry Commons

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