Campus Units

Chemistry

Document Type

Article

Publication Version

Submitted Manuscript

Publication Date

8-18-2017

Journal or Book Title

Organic Letters

Volume

19

Issue

16

First Page

4159

Last Page

4162

DOI

10.1021/acs.orglett.7b01535

Abstract

Molecular recognition of water-soluble molecules is challenging but can be achieved if the receptor possesses a hydrophobic binding interface complementary to the guest. When the guest molecule contains more than one hydrophobic group, intrahost interactions between the hydrophobes could strongly influence the binding of the guest by its host. In a series of ornithine derivatives functionalized with aromatic hydrophobes, the most electron-rich compound displayed the strongest binding, despite its lowest intrinsic hydrophobicity.

Comments

This document is the unedited Author’s version of a Submitted Work that was subsequently accepted for publication in Organic Letters, copyright © American Chemical Society after peer review. To access the final edited and published work see DOI: 10.1021/acs.orglett.7b01535. Posted with permission.

Copyright Owner

American Chemical Society

Language

en

File Format

application/pdf

Published Version

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