Campus Units
Chemistry
Document Type
Article
Publication Version
Submitted Manuscript
Publication Date
8-18-2017
Journal or Book Title
Organic Letters
Volume
19
Issue
16
First Page
4159
Last Page
4162
DOI
10.1021/acs.orglett.7b01535
Abstract
Molecular recognition of water-soluble molecules is challenging but can be achieved if the receptor possesses a hydrophobic binding interface complementary to the guest. When the guest molecule contains more than one hydrophobic group, intrahost interactions between the hydrophobes could strongly influence the binding of the guest by its host. In a series of ornithine derivatives functionalized with aromatic hydrophobes, the most electron-rich compound displayed the strongest binding, despite its lowest intrinsic hydrophobicity.
Copyright Owner
American Chemical Society
Copyright Date
2017
Language
en
File Format
application/pdf
Recommended Citation
Gunasekara, Roshan W. and Zhao, Yan, "Intrinsic Hydrophobicity versus Intraguest Interactions in Hydrophobically Driven Molecular Recognition in Water" (2017). Chemistry Publications. 1213.
https://lib.dr.iastate.edu/chem_pubs/1213
Comments
This document is the unedited Author’s version of a Submitted Work that was subsequently accepted for publication in Organic Letters, copyright © American Chemical Society after peer review. To access the final edited and published work see DOI: 10.1021/acs.orglett.7b01535. Posted with permission.