Journal or Book Title
Natural Toxins 2. Advances in Experimental Medicine and Biology
The fumonisins and AAL-toxin are structurally-related natural products produced by fungi (22, 23, 24). Fumonisin B1 [FB1] has been recognized since 1988 as a mammalian toxin (36, 37, 44, 52). More recently, FB1 has been shown to be a phytotoxin as well (1,2,3). AAL-toxin has been known to produce symptoms of stem canker disease on susceptible (asc/asc) tomatoes (9, 48, 56, 58). Our research has focused on evaluating the potential of the class of natural products defined by AAL-toxin and the fumonisims for the development of improved weed control agents. This work has involved the development of improved methods for the isolation, purification and characterization of these toxins. Useful methods have been developed for assessing phytotoxicity of these toxins with various weed species, and for estimating mammalian toxicity. A series of analogs has been obtained, either derivatizing the parent toxins or by de novo synthesis, and evaluated for phytotoxicity and mammalian cytotoxicity. Characterization of the toxins has included studies on their mode of action in plant tissue, their ability to act as sphingosine analogs and their stereochemistry.
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Abbas, H. K.; Duke, S. O.; Shier, W. T.; Riley, R. T.; and Kraus, George A., "The Chemistry and Biological Activities of the Natural Products AAl-Toxin and the Fumonisins" (1996). Chemistry Publications. 1219.