Campus Units

Chemistry, Ames Laboratory

Document Type


Publication Version

Accepted Manuscript

Publication Date


Journal or Book Title

Journal of Chromatography A

First Page





Deep eutectic solvents (DESs) have emerged as alternatives to conventional organic solvents and ionic liquids (ILs). Their tunable and designer physio-chemical properties, low cost, and ease of preparation make them attractive solvent systems for use in extractions and additives to chromatographic separations. However, due to the diverse range of hydrogen bond acceptors and donors that comprise DESs, choosing the appropriate solvent for separations can be challenging. This review discusses all methods of DES preparation and details their advantages and disadvantages. Since polarity is an important aspect in their use in separations, the classification of DESs based on the betaine dye and nile red scales as well as Kamlet-Taft parameters is also discussed. Finally, a summary of applications of DESs in various extraction processes (phenolics, fuels, metals, proteins, carbohydrates), solid-phase extraction, solid-phase microextraction, as well as capillary electrochromatography is provided.


This article is published as Farooq, Muhammad Qamar, Nabeel Mujtaba Abbasi, and Jared L. Anderson. "Deep Eutectic Solvents in Separations: Methods of Preparation, Polarity, and Applications in Extractions and Capillary Electrochromatography." Journal of Chromatography A (2020): 461613. DOI: 10.1016/j.chroma.2020.461613. Posted with permission.

Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

Copyright Owner

Elsevier B.V.



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Available for download on Tuesday, October 11, 2022

Published Version