Campus Units

Chemistry

Document Type

Article

Publication Version

Published Version

Publication Date

2020

Journal or Book Title

Organic & Biomolecular Chemistry

Volume

18

Issue

3

First Page

495

Last Page

499

DOI

10.1039/C9OB02486G

Abstract

A robust lipophilic dye, based on the structures of the benzothiadiazole heterocycle, was shown to be a potent fluorescent stain for the selective imaging of lipid droplets (LDs) within both live and fixed human cells. Its small molecular framework, large Stokes shift, and vastly improved photostability over that of the current status quo, Nile Red, highlight its tremendous potential as a versatile chemical tool for facilitating LD imaging and research.

Comments

This article is published as Suarez, S. Israel, Caroline C. Warner, Heather Brown-Harding, Andrea M. Thooft, Brett VanVeller, and John C. Lukesh. "Highly selective staining and quantification of intracellular lipid droplets with a compact push–pull fluorophore based on benzothiadiazole." Organic & Biomolecular Chemistry 18, no. 3 (2020): 495-499. DOI: 10.1039/C9OB02486G. Posted with permission.

Creative Commons License

Creative Commons Attribution-Noncommercial 3.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial 3.0 License

Copyright Owner

The Royal Society of Chemistry

Language

en

File Format

application/pdf

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