Campus Units

Chemistry

Document Type

Article

Publication Version

Accepted Manuscript

Publication Date

1-2-2018

Journal or Book Title

Chemistry - A European Journal

Volume

24

Issue

10

First Page

150

Last Page

158

DOI

10.1002/chem.201703760

Abstract

Sequence‐specific recognition of peptides is of enormous importance to many chemical and biological applications, but has been difficult to achieve due to the minute differences in the side chains of amino acids. Acidic peptides are known to play important roles in cell growth and gene expression. In this work, we report molecularly imprinted micelles coded with molecular recognition information for the acidic and hydrophobic side chains of acidic peptides. The imprinted receptors could distinguish acidic amino acids from other polar and nonpolar amino acids, with dissociation constants of tens of nanomolar for biologically active peptides containing up to 18 amino acids.

Comments

This is the peer-reviewed version of the following article: Fa, Shixin, and Yan Zhao. "Water‐Soluble Nanoparticle Receptors Supramolecularly Coded for Acidic Peptides." Chemistry–A European Journal 24, no. 1 (2018): 150-158, which has been published in final form at DOI: 10.1002/chem.201703760. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. Posted with permission.

Copyright Owner

Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim

Language

en

File Format

application/pdf

Published Version

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