Campus Units

Chemistry

Document Type

Article

Publication Version

Published Version

Publication Date

2020

Journal or Book Title

Chemical Communications

Volume

56

Issue

70

First Page

10199

Last Page

10202

DOI

10.1039/D0CC02892D

Abstract

Although synthetic mimics of lectins can be extremely useful in biological and biomedical research, molecular recognition of carbohydrates has been hampered by their strong solvation in water and subtle structural differences among analogues. Molecularly imprinted nanoparticle receptors were prepared with glycans directly cleaved from glycoproteins. Functionalized with boroxole groups in the binding sites, these water-soluble synthetic lectins bound the parent glycoproteins selectively in water with an association constant of Ka = 104–105 M−1. The strong binding enabled the receptors to protect the targeted glycans from enzymatic cleavage. When clicked onto magnetic nanoparticles, the receptors enabled facile isolation of glycoproteins from a mixture.

Comments

This article is published as Duan, Likun, Milad Zangiabadi, and Yan Zhao. "Synthetic lectins for selective binding of glycoproteins in water." Chemical Communications 56, no. 70 (2020): 10199-10202. DOI: 10.1039/D0CC02892D. Posted with permission.

Creative Commons License

Creative Commons Attribution-Noncommercial 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License

Copyright Owner

The Royal Society of Chemistry

Language

en

File Format

application/pdf

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