Campus Units

Chemistry

Document Type

Article

Publication Version

Published Version

Publication Date

3-16-2021

Journal or Book Title

Angewandte Chemie International Edition

DOI

10.1002/anie.202102148

Abstract

Proteolysis of proteins and peptides is involved in the infection of cells by enveloped viruses and also in the invasion and spread of cancer cells. Shutting down broad‐specificity proteases, however, is problematic because normal functions by these proteases will be affected. Herein, nanoparticle receptors were prepared from molecular imprinting for complex biological peptides. Their strong and selective binding enabled them to protect their targeted sequences from proteolysis in aqueous solution at stoichiometric amounts. Generality of the method was demonstrated by the protection of hydrophobic and hydrophilic peptides from different proteases, selective protection of a segment of a long peptide, and selective protection of a targeted peptide in a mixture. Most interestingly, two receptors targeting different parts of a long peptide could work in cooperation to protect the overall sequence, highlighting the versatility of the method.

Comments

This is the published version of the following article: Li, Xiaowei, Kaiqian Chen, and Yan Zhao. "Sequence‐Selective Protection of Peptides from Proteolysis." Angewandte Chemie International Edition (2021). DOI: 10.1002/anie.202102148. Posted with permission.

Creative Commons License

Creative Commons Attribution-NonCommercial 4.0 International License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License

Copyright Owner

The Author(s)

Language

en

File Format

application/pdf

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