Campus Units

Chemistry

Document Type

Article

Publication Version

Published Version

Publication Date

7-2010

Journal or Book Title

Journal of the American Chemical Society

Volume

132

Issue

31

First Page

10642

Last Page

10644

DOI

10.1021/ja103391k

Abstract

Hydrophobic guests such as pyrene could be readily trapped inside the micelles of an alkynylated surfactant in the presence of an azide-functionalized cross-linker using the click reaction. The cross-linker was designed to contain cleavable bonds such as geminal diol, disulfide, and acetal. The resulting pyrene-containing water-soluble nanoparticle was under electrostatic stress when diluted below the CMC of the surfactant. Extremely rapid (<1 min) release of the hydrophobic content was observed when the cross-linker was cleaved. This method combines the ease of physical entrapment and the precision of chemical ligation, and potentially is highly useful in the delivery and controlled release of pharmaceutical agents.

Comments

Reprinted (adapted) with permission from Journal of the American Chemical Society 132 (2010): 10642, doi:10.1021/ja103391k. Copyright 2010 American Chemical Society.

Copyright Owner

American Chemical Society

Language

en

File Format

application/pdf

Included in

Chemistry Commons

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