Campus Units

Chemistry

Document Type

Article

Publication Version

Published Version

Publication Date

8-2012

Journal or Book Title

Bioconjugate Chemistry

Volume

23

Issue

9

First Page

1721

Last Page

1725

DOI

10.1021/bc300082b

Abstract

Water-soluble organic nanoparticles were prepared by cross-linking the micelles of a tripropargylated cationic surfactant by a diazide cross-linker in the presence of Cu(I) catalysts. The nanoparticles were decorated with hydrophilic ligands of different lengths on the surface. By interacting with negatively charged liposomes through tunable electrostatic interactions, these nanoparticles induced fusion and leakage of large unilamellar vesicles (LUVs). Fusion or aggregation of the membranes was highly sensitive to the rigidity and phase structures of the membranes, enabling thermally gated fusion to occur within a very narrow window of temperature change.

Comments

Reprinted (adapted) with permission from Bioconjugate Chemistry 23 (2012): 1721, doi:10.1021/bc300082b. Copyright 2012 American Chemical Society.

Copyright Owner

American Chemical Society

Language

en

File Format

application/pdf

Included in

Chemistry Commons

Share

COinS