Campus Units

Chemistry

Document Type

Article

Publication Version

Published Version

Publication Date

3-2015

Journal or Book Title

Langmuir

Volume

31

Issue

13

First Page

3919

Last Page

3925

DOI

10.1021/acs.langmuir.5b00379

Abstract

Membrane curvature is an important parameter in biological processes such as cellular movement, division, and vesicle fusion and budding. Traditionally, only proteins and protein-derived peptides have been used as sensors for membrane curvature. Three water-soluble bischolate foldamers were synthesized, all labeled with an environmentally sensitive fluorophore to report their binding with lipid membranes. The orientation and ionic nature of the fluorescent label were found to be particularly important in their performance as membrane-curvature sensors. The bischolate with an NBD group in the hydrophilic α-face of the cholate outperformed the other two analogues as a membrane-curvature sensor and responded additionally to the lipid composition including the amounts of cholesterol and anionic lipids in the membranes.

Comments

Reprinted (adapted) with permission from Langmui 31 (2015): 3919, doi:10.1021/acs.langmuir.5b00379. Copyright 2015 American Chemical Society.

Copyright Owner

American Chemical Society

Language

en

File Format

application/pdf

Included in

Chemistry Commons

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